Relax, Don’t RAN Translate It

Cardio-oncology: it takes two to translate.

As an emerging discipline focused on the cardiovascular care of cancer patients, cardio-oncology represents a novel platform for translational investigations. Toxic effects on the heart and vasculature caused by targeted cancer therapies can reveal insights into the biology of cardiovascular disease in humans. This phenomenon was first observed with trastuzumab, a monoclonal antibody that targe...

Preclinical investigations for thrombectomy devices--does it translate to humans?

I Dont Want to Hear About it: Rational Ignorance among Morally Motivated Consumers

Individuals with a preference for keeping moral obligations may have an incentive to avoid information indicating that voluntary contributions are socially valuable. The reason is that such information can increase these individuals’perceived burden of responsibility. An increase in the believed social value of contributions a¤ects neither behavior nor the utility of Homo Economicus and of the ...

Now You See It, Now You Dont: how social cues and questions misdirect our attention

Magic tricks offer powerful tools to manipulate people’s attention and conscious experience. Using realworld eyetracking we can investigate how different misdirection cues drive people’s eye movements. Moreover, by measuring people’s susceptibility to the trick, we can evaluate how these cues influence people’s conscious experience. We used a magic trick to explore the way in which spoken quest...

Ran

How is Ran involved in nuclear transport? Cargo is transported through pores in the nuclear envelope, in association with carriers that bind to pore proteins called nucleoporins. A Ran–GTP gradient across the envelope is created by the asymmetric distribution of the GTPase activating protein known as RanGAP, which is in the cytosol, and of the guanine nucleotide exchange factor RanGEF in the nu...